NUDT5, (10p14) YSA1 ADP-sugar pyrophosphatase

https://www.ncbi.nlm.nih.gov/gene/11164

Also known as

YSA1; YSA1H; YSAH1; hNUDT5

Summary

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

Expression

Ubiquitous expression in liver (RPKM 12.0), skin (RPKM 11.4) and 25 other tissues See more

Orthologs

mouse all

Preferred Names

ADP-sugar pyrophosphatase

Names

8-oxo-dGDP phosphatase

nuclear ATP-synthesis protein NUDIX5

nudix (nucleoside diphosphate linked moiety X)-type motif 5

NP_001308576.1

• EC 2.7.7.96

• EC 3.6.1.13

• EC 3.6.1.58

Related articles in PubMed

1. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Page BDG, et al. Nat Commun, 2018 Jan 17. PMID 29343827, Free PMC Article
2. Lowered Nudix type 5 expression leads to cellular senescence in IMR-90 fibroblast cells. Zhang L, et al. Free Radic Res, 2013 Jul. PMID 23581889
3. [Mechanistic insight into hydrolysis of oxidized nucleotide diphosphates by human NUDT5]. Arimori T, et al. Fukuoka Igaku Zasshi, 2011 Nov. PMID 22351996
4. Lowered nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells. Zhang LQ, et al. Mol Cell Biochem, 2012 Apr. PMID 22200976
5. Diverse substrate recognition and hydrolysis mechanisms of human NUDT5. Arimori T, et al. Nucleic Acids Res, 2011 Nov 1. PMID 21768126, Free PMC Article

GeneRIFs: Gene References Into Functions

1. Data suggest that targeting nudix hydrolase 5 (NUDT5) may represent a promising new therapeutic approach for breast cancer treatment.
2. In the presence of pyrophosphate, ADP-ribose is used by the pyrophosphatase NUDIX5 to generate nuclear ATP.
3. The NUDT5 protein could play significant roles in the prevention of RNA oxidation and survival in human fibroblast cells.
4. Results suggest that the NUDT5 protein may play significant roles in regulating the G1-S transition in HeLa cells.
5. The human NUDT5, which has an intrinsic activity to cleave ADP sugars to AMP and sugar phosphate, possesses the ability to degrade 8-oxo-dGDP to the monophosphate.
6. The broad substrate specificity of hNUDT5 is achieved by a diversity of not only substrate recognition, but also hydrolysis mechanisms.
7. human MTH1, MTH2, and NUDT5 proteins act as a defense against the mutagenesis induced by oxidized dGTP.
8. NUDT5 protein eliminates various oxidized deoxyribonucleoside diphosphates from the nucleotide pool and prevents their toxic effects.
9. Results report the crystal structure of hNUDT5 in complex with a non-hydrolyzable ADPR analogue, alpha,beta-methyleneadenosine diphosphoribose, and three Mg(2+) ions representing the transition state of the enzyme during catalysis.
10. degrades 8-oxo-dGDP to 8-oxo-dGMP, an unusable form for DNA synthesis, and promotes the cleavage of 8-oxo-dGTP by MTH1 to yield 8-oxo-dGMP also

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