Happamattoman leivän eduista

 Näin paaston aikoina voi ottaa esiin yhden  asian happamattoman leivän eduista, mitä Luoja on Sanassaan tarjonnut ihmiskunnalle jo vuosituhansien ajan.

Kuten AI tietää epäorgaaniset fosfaatit ravinnossa toimivat kuin lihotusrehun ainesosa ja aiheuttaa ulipainoa vuosien varrella, jos asiaan ei kiinnitä huomiota.

Happamaton leipä tarkoittaa, että leivän valmistuksess ei käytetä  hiivoja, joissa on fytaaseja, orgaanista luonnonfosfaattimuotoa pilkkovia entsyymejä  ja sigen  fosfaatit viljoista pysyttelevät  pafremmin fytiinimuotoisena inositgolihexafosfaattina kauamman aikaa ja  antavat lopulta  keholle sen tarvitsemaa antioksidanteista erästä voimakkainta molekyyliä  inositoliheksafosfaattimuotoa. Jos vilja hapagtetaan tämä muoto  pilkkoo irti fosfaatteja epäorgaanisiin muotoihin  ja   inositolisokerialkoholirengas muotoonkin. Hetkellisdssti tällaisesta    ravinosta ei tietyti ole haittoja, mutta vuositolkulla  viljan hajoittaminen fytaaseilla on  vähentänyt suhteellista osuutta orgaanisen ja epäorgaanisen fosfaatin välillä kehossa ja se  kääntynyt suhde aiheuttaa metabolisen  häiriön. 

Israelilaist tuskin aattelevat tätä fosfaattien  toipunutta suhdetta pääsiäisen ja helluntain välisenä aikana kun käyttävät  happamattomia  leipiä ja  muroja, jyviä paahdettuina  kevään läpi- Laki vaatii vain 7 happamattoman leivän päivää, mutta moni jatkaa koko  40 päivän ajan  happamattoman viljatuotteen käyttöä. Happamattoman leivän tuotaqnto on niin suuri pääsiäiseksi että sitä riittää kyllä koko kevään väestölle.  Helluntain hapatettuun leipään asti.  Tästä on seurauksena  se  sirous ja keveys ortodoksisen kansan kehossa ja heidän  uskonollisten tanssiensa  jalan keveät nousut ja  väestön  jaksaminen  siellä vuorimaastossa ikäänkuin siivitettnä  - turistin silmin katsoen. 

Sen sijaan kristikunta gekee  hiivalla valmistettua leipää  tasaisesti vuoden lpi, juhlina leivonnaistg on kaksin verroin.  Lisäaineissa o n monia  epäorgaanisia fosfaatteja  sisältäviä. Lis-ksi natriumbikarbonaatit nostoaineina leivonnaisdessa   nosgtavat natriumrsitusta keholla.  Leivonnaisissa on myös usei runastga sokerilisää, mikä kilpailee myoinositoliaineenvaihdunnan  kanssa..  Inositolia, orgaanisdestga  fosforista jääbyttä  lopputuotesokerimuotoa  menetetään  liika sokerivoittoisuuden takia, varsinkin diabeteksessa. 

Miten tästä  kristikunnan hyvinvoinin kierteen haittatilanteesgta voisi  päästä  irti  ilman että  hengelliset tunteet  kärsivät ja  Lain Hengestä  vapautunut sielu  ei katso olevan mitään hyötyä  lakiin kuuluneen  maallisen elämänmenon rutiineista. Mutta nyt on niin ett ei vain Mooseksen Laki vaan ihan tavallinen AI järki  antaa käsittää liian epäorgaanisen fosfaatin paineen tulevan kehoon ihmisen valitseman  ravinnon  kautta. Jos tarkkailee  yksityiskohtaisesti   vanhatestamentillisia  ruokaohjeita, huomaa   nykyajan  tarkimman tiedon  yllättäen päätyvän  oivaltamaan  terveydelliset  sofistiset hienoudet, mitä Luoja jo  Mooseksen aikana ja jo Aadamin päivistä ihmiskunnalle  neuvoi.Vihannekset,  siementä tekevät ruohot, siemenet, hedelmt toimivat  fytiinilähteinä ( antavat luonnollisia orgaanisia fosfattimuotoja).

Myöhemmin tuleet ohjeet lihan syönnistä  myös  antaa  analyyttisesti yhteenvetäen välttöohjeita  epäorgaaniesta fosfaatista. 

Yleensä ravintotaulukot ilmoittavat  vain  fosforina  fosfaatit gtekemättä eroa  epäorgaanisen j orgaanisen fosfaatin välillä. Kuitenkin  on olemassa fytiinipitoisuuksista  taulukoita joita voi käyttää apuna tarkistaessaan  fytiininsä saannin. samalla voi tarkistaa että  ei käytä  epäorgaanisia fosfaattilisäaineita  ravinnossaan  huomaamattaan.(epäorgaanisten fosfaattien nmiä FAOn tutkimuksessa.https://www.inchem.org/documents/jecfa/jecmono/v48aje11.htm)

Happamattomia leipämuotoja on tarjolla kyllä  muistakin syistä kuin  uskonnollisita syistä.  esim riisikeksejä, maissikeksejä-  Happamatont ovat  müslit,  paahdetutjyvät,, vohvelit, lätyt, riisipannukakku. Luonnollissti kaikki puurot.

 Raamatullinen Jaakobin hernekeitto on hyvä fytiinilähde kuten  pavut, virvilät,  Täytyy vain liottaa 6-12 tuntia papuja yön yli, poistaa huuhteluvesi ja sitten keittää 100 asteessa kiehuttaaen puolisen tuntia että haitalliset mahavaivoja aiheuttavat lektiinit  pehmenevät.   Pähkinöissä ja manteleissa on  runsaasti Fytiiniä (IP6)..

Huomaa miten prosessointi vähentää fytiiniantia (IP6 muotoa). Fosfaatin  koko määä ei ole ilmaisu tässä taulukossa.

Food	Moisture %	Serving	Size(g)	Phytin/ serving	Edible (mg/100g	Phytin (mg/ 100g)
Almonds( Taylors Sunshine Colony)	5.0	½ c	71	909	347	1280
Apples, raw, not pared	84.4	1	150	94	63	404
Artichoke, Jerusalem, boiled	80.2	1 bud	380	110	29	146
Artichoke, Jerusalem, flour	10.9	1 tbsp	15	70	468	525 ± 24
Artichoke hearts, whole (S & W)	90.0	1	120	11	1	88 ± 2
Avocado	66.1	1	201	2	1	3 ± 2
Bacon Chips, imitation( Bacos, Betty Crocker)	5.0	1 tbsp	15	196	1310	1379 ± 9
Baking mix, buttermilk( Bimix, Martha White)	7.5	1 tbsp	15	27	180	195 ± 14
Barley, infant cereaö, instant cooking, dry ( Gerber)	10.3	1 oz	28	251	897	1000
Barley, pearl, boiled	69.6	½ c	120 g	197	164	539
Beans, broad, boiled	83.7	½ c	120 g	22	18	110
Beans, green, casserole with cheddar cheese	70.0	1 c	124 g	112	90	300
Beans, kidney, canned, drained	69.0	½ c	92	282	307	990 ±2
Beans, lima, immature, raw	67.5	½ c	55	124	226	695 ± 9
Beans, lima, mature, dry, raw	10.3	¼ c	40	404	1010	1126
Beans, navy, mature, dry, boiled, drained	69.0	½ c	85	294	346	1116
Beans, navy, mature, dry, raw	10.9	½ c	62	564	910	1021 ±18
Beans, pinto, raw	67.5	½ c	55	122	222	684 ±5
Beans, snap, green, canned, drained	91.9	½ c	62	56	91	1123
Beets, canned, sliced ( Del Monte)	90.7	½ c	85	2	3	30 ± 7
Blackberries	82.0	½ c	72	7	10	56
Blueberries, sweeten- ed, canned, drained	72.3	½ c	115	3	3	11 ± 4
Boullion cubes, beef flavoured ( Wylers)	4.0	2 cubes	8	7	88	92 ±2
Bouillion cubes, chicken flavoured(Wylers)	4.0	2 cubes	8	3	32	33±2
Brazil nuts	8.5	½ c	70	1259	1799	1966
Bread, French	30.6	1 slice	35	6	17	24
Bread, High Fiber, wheat (Fresh Horizon)	36.4	1 sl	28	65	232	365 ± 2
Bread. High fiber, white(Fresh Horizon)	35.8	1 sl	27	21	79	123 ±1
Bread, Norwegian, flat( Kauli)	4.3	1	10	65	654	683 ± 3
Bread , pita (Giant)	25.0	1	35	43	123	164 ± 2
Bread, pumper- Nickel (Giant)	34.0	1 sl	32	34	107	162

   

DCI, D-Chiro-inositoli , myo-inositoli ja fytiini ( inositolihexafosfaatti)

https://D-chiro-inositol hexakisphosphate (D-chiro-IP6pmc.ncbi.nlm.nih.gov/articles/PMC12472782/

One emerging therapeutic avenue involves the modulation of insulin signaling, as insulin resistance is increasingly recognized as a central contributor to AD pathophysiology. Often referred to as “type 3 diabetes” [9], AD has been linked to impaired insulin signaling, which disrupts glucose metabolism, neuronal survival, and synaptic plasticity, thereby exacerbating neurodegeneration [6,9,10,11]. Insulin signaling in the central nervous system (CNS) is mediated through the phosphoinositide 3-kinase (PI3K)/AKT pathway, which is critical for energy homeostasis, neurotransmission, and synaptic integrity [12,13]. Defects in this pathway have been observed in AD patients and are associated with neuronal energy deficits, oxidative stress, and increased vulnerability to Aβ toxicity [12,13,14]. Furthermore, insulin resistance impacts glutamatergic neurotransmission, particularly through dysregulation of N-methyl-D-aspartate receptors (NMDARs), contributing to excitotoxicity, synaptic dysfunction and cognitive impairment [15,16,17].

In this context, insulin sensitizers such as D-chiro-inositol (DCI) represent a promising intervention for restoring insulin signaling in AD.

 DCI is a naturally occurring inositol isomer that can be incorporated into the body through diet and plays a crucial role in insulin-mediated glucose uptake and metabolism by acting through the PI3K/AKT pathway [18,19]. In addition to improving insulin sensitivity, DCI has been implicated in modulating neuroinflammatory responses and oxidative stress, which are key drivers of AD pathology [20,21,22]. Given its role in metabolic regulation, PI3K/AKT signaling [23], DCI may also influence glutamatergic signaling by stabilizing NMDAR function, potentially reducing excitotoxicity and synaptic deficits observed in AD. Preliminary observations indicate that DCI has beneficial effects in AD by counteracting the toxic actions of Abeta oligomers and by normalizing metabolic dysfunctions associated with amyloidosis in the humanized 5XFAD model of AD [24,2.....

. 2020 Apr 10;25(7):1720. doi: 10.3390/molecules25071720

New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review

Felix O Omoruyi ¹, Dewayne Stennett ², Shadae Foster ², Lowell Dilworth ^3,*

Editor: Ivana Vucenik

PMCID: PMC7212753  PMID: 32290029

. Inositol

Inositol is a saturated polyol with a six-carbon ring structure where each carbon is hydroxylated. They are isomers of hexahydroxy-cyclohexanes with nine possible geometrical forms, seven of which are optically inactive, and the remaining two form a chiral pair [10]. Some are biologically active, with the most common and most stable being myo-inositol [11,12]. Myo-inositol is water-soluble and found in a variety of food products [13]. Different safe doses of inositol have been reported in the literature. A daily oral dose of 18 g of inositol for three months has been reported to be safe and well-tolerated [14]. Others have suggested that myo-inositol is safe up to doses of 12 g per day [15]. Clements and Darnell [16] observed that the greatest amounts of myo-inositol were present in fruits, beans, grains, and nuts. Myo-inositol serves as the backbone and precursor of other inositol phosphates. It is produced in the human body from d-glucose and is present in all living cells as phosphatidylinositol and phytic acid [17]. It plays important physiological roles, which include mediation of osmoregulation, anticancer activity, and the enhancement of the anticancer effects of IP6 on various cancers [18,19,20]. It is also involved in the regulation of insulin release from the pancreatic beta-cells [21,22,23,24].

3. Myo-Inositol Hexakisphosphate

Myo-inositol hexakisphosphate (IP6), or phytic acid, is a natural organic phosphorus compound that is present in almost all plant and mammalian cells and is the phosphorus reservoir in all grains and oilseeds [25]. It is found in food sources high in fiber content, with the most abundant sources being wheat bran and flaxseed (0.4–6.4%) [26,27]. In most cereal crops, IP6 is the primary source of phosphorus. It possibly accounts for 65–85% of the total phosphorus in seeds, with the remaining phosphorus in the form of soluble inorganic phosphate and cellular phosphorus found in macromolecules such as nucleic acids, proteins, lipids and sugars [28,29].

The antinutrient nature of IP6 has been described in some studies [30,31]. However, emerging research shows that IP6, as well as the lower forms of inositol phosphates, IPs 2–5, may have essential physiological functions as well as anti-inflammatory and anticancer properties [32,33,34,35]. Recent studies have ascribed antioxidant and anti-diabetic properties to this group of compounds [36,37]. IP6 is produced within cells by de novo synthesis [38]. It is biosynthesized via two different routes, the lipid-dependent and lipid-independent pathways [39,40]. In plants, the lipid-dependent pathway is prominent in all plant organs, and the lipid-independent pathway is the more prominent of the two pathways in seeds only [41 d-glucose-6-phosphate is initially converted to myo-inositol 3-monophosphate by the enzyme myo-inositol 3-phosphate synthase. In the lipid-independent pathway, the myo-inositol 3-monophosphate undergoes a series of sequential phosphorylations through the action of various inositol phosphate kinases (Figure 1). For the lipid-dependent pathway, the myo-inositol 3-monophosphate is initially converted to myo-inositol, which is then converted to various phosphatidyl inositols, eventually leading to the formation of the higher inositol phosphates, IP5 and IP6 (Figure 1)

Fytiinin ja inositolin parhaat lähteet ovat  ekonomisesti edullisimmissa  ravintoaineissa, pavuissa, herneissä, pähkinöissä, manteleissa, viljan siemenissä, hedelmissä-

AXIS IRE1alfa-TRAF2-ASK1 ja mahdollisesti IRE1 beta.

 ERN1 eli IRE1beta

ASK1

https://pmc.ncbi.nlm.nih.gov/articles/PMC9038009/

Kesken

ENDOLYMFA, jonitasapainon säätelystä . Tärkeä kuuloaistin tarkkuudelle ja endogeenin taustahälyn vaimennukselle.

 https://pubmed.ncbi.nlm.nih.gov/35112133/

PubMed HAKU: Na+, K+, Cl-, ENDOLYMPHA.

•  2022 May;474(5):505-515.

doi: 10.1007/s00424-021-02661-9. Epub 2022 Feb 3. Low-salt diet increases mRNA expression of aldosterone-regulated transporters in the intermediate portion of the endolymphatic sac

Ai Matsubara ^{#  1} , Takenori Miyashita ^{#  2} , Kentaro Nakashima  ³ , Nozomu Mori  ² , Si-Young Song  ³ , Hiroshi Hoshikawa  ²

Affiliations

• PMID: 35112133
• DOI: 10.1007/s00424-021-02661-9

 Abstract

The endolymphatic sac is a small sac-shaped organ at the end of the membranous labyrinth of the inner ear. The endolymphatic sac absorbs the endolymph, in which the ion balance is crucial for inner ear homeostasis. Of the three sections of the endolymphatic sac, the intermediate portion is the center of endolymph absorption, particularly sodium transport, and is thought to be regulated by aldosterone. Disorders of the endolymphatic sac may cause an excess of endolymph (endolymphatic hydrops), a histological observation in Meniere’s disease. A low-salt diet is an effective treatment for Meniere’s disease, and is based on the assumption that the absorption of endolymph in the endolymphatic sac abates endolymphatic hydrops through a physiological increase in aldosterone level. However, the molecular basis of endolymph absorption in each portion of the endolymphatic sac is largely unknown because of difficulties in gene expression analysis, resulting from its small size and intricate structure. The present study combined reverse transcription-quantitative polymerase chain reaction and laser capture microdissection techniques to analyze the difference of gene expression of the aldosterone-controlled epithelial Na⁺ channel, thiazide-sensitive Na⁺-Cl⁻ cotransporter, and Na⁺, K⁺-ATPase genes in the three individual portions of the endolymphatic sac in a rat model. A low-salt diet increased the expression of aldosterone-controlled ion transporters, particularly in the intermediate portion of the endolymphatic sac. Our findings will contribute to the understanding of the physiological function of the endolymphatic sac and the pathophysiology of Meniere’s disease.

 

 

ENDOLYMPHA, glukoosi...PubMed haku , 30 artikkelia

HAKU PubMed: Endolympha, glucose

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1

Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model.

Lee YY, Kim YJ, Gil ES, Kim H, Jang JH, Choung YH. Biomedicines. 2020 Sep 11;8(9):343. doi: 10.3390/biomedicines8090343. PMID: 32932780 Free PMC article.

The Akita mice had a significant increase in hearing thresholds, blood glucose, and insulin tolerance compared to WT mice. Histological analysis showed that the loss of cells and damage to mitochondria in the spiral ganglion neurons of Akita mice were significantly increas …

2

Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.

Chen B, Wang Y, Geng M, Lin X, Tang W. Biomed Res Int. 2018 Jun 14;2018:7817453. doi: 10.1155/2018/7817453. eCollection 2018. PMID: 30013986 Free PMC article.

This study aimed to investigate the localization pattern of glucose transporters (Gluts) in mouse cochlea. Genome-wide gene expression analysis using CodeLink bioarrays indicated that Glut1 and Glut10 were highly expressed (~10-fold) in mouse cochlea compared with the othe …

3

Differential localizations of the myo-inositol transporters HMIT and SMIT1 in the cochlear stria vascularis.

Edamatsu M, Kondo Y, Ando M. Neurosci Lett. 2018 May 1;674:88-93. doi: 10.1016/j.neulet.2018.03.028. Epub 2018 Mar 15. PMID: 29551423

The cochlear stria vascularis produces endolymph and thereby plays an active role in inner ear homeostasis. We recently reported that the H(+)/myo-inositol cotransporter (HMIT) gene is expressed in the stria vascularis. ...

4

The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion.

Miyazaki H, Wangemann P, Marcus DC. BMC Physiol. 2016 Aug 11;17(1):1. doi: 10.1186/s12899-016-0024-1. PMID: 27515813 Free PMC article.

The acid flux was decreased to about 40 % of control by removal of the metabolic substrate (glucose-free) and by inhibition of the sodium pump (ouabain). The flux was also decreased a) by inhibition of Na,H-exchangers by amiloride, dimethylamiloride (DMA), S3226 and Hoe694 …

5

Mitochondrial diabetes and deafness: possible dysfunction of strial marginal cells of the inner ear.

Olmos PR, Borzone GR, Olmos JP, Diez A, Santos JL, Serrano V, Cataldo LR, Anabalón JL, Correa CH. J Otolaryngol Head Neck Surg. 2011 Apr;40(2):93-103. PMID: 21453644 Review.

One of our MIDD patients inspired us to propose an integrated view on how a single mutation of the mitochondrial deoxyribonucleic acid (DNA) affects both the glucose metabolism and the inner ear physiology. DESIGN: (a) Study of mitochondrial DNA in a patient with MIDD. (b) …

6

Cellular localization of facilitated glucose transporter 1 (GLUT-1) in the cochlear stria vascularis: its possible contribution to the transcellular glucose pathway.

Ando M, Edamatsu M, Fukuizumi S, Takeuchi S. Cell Tissue Res. 2008 Mar;331(3):763-9. doi: 10.1007/s00441-007-0495-2. Epub 2008 Jan 15. PMID: 18196278

Immunoreactivity for the facilitated glucose transporter 1 (GLUT-1) has been found in the cochlear stria vascularis, but whether the strial marginal cells are immunopositive for GLUT-1 remains uncertain. ...The three-dimensional relationship between marginal cells and basa …

7

The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene.

Warth R, Barhanin J. Am J Physiol Regul Integr Comp Physiol. 2002 Mar;282(3):R639-48. doi: 10.1152/ajpregu.00649.2001. PMID: 11832382 Free article. Review.

Like patients, knockout mice are deaf and show vestibular symptoms due to an impaired endolymph production. Knockout mice show urinary and fecal salt wasting and volume depletion. The renal phenotype is due to diminished reabsorption of Na(+) and glucose. The mice a …

8

Effects of endolymphatic duct occlusion on the structure and function of the endolymphatic sac in the adult guinea pig.

Lee AJ, Parker DA, Gladstone HB, Hradek G, Schindler RA. Laryngoscope. 1995 Feb;105(2):192-7. doi: 10.1288/00005537-199502000-00016. PMID: 8544603

The present study was designed to determine the ELS response to slower changes in fluid dynamics by occluding the endolymphatic duct (ELD), thereby interrupting the longitudinal flow of endolymph to the ELS. Morphologic studies and autoradiographic techniques were used to …

9

Changes in hyaluronan synthesis by in vitro cultured endolymphatic sac cells.

Amoils CP, Schindler RA, Parker DA, Hradek GT. Am J Otol. 1992 Jul;13(4):343-6. PMID: 1415498

This model was chosen to determine whether a change in endolymph homeostasis affects ELS activity. Radiolabeled 14C glucose incorporation was used to evaluate HA synthesis by ELS cells when cultured in vitro. ...Therefore, the ELS cells of intact otocysts incorporat …

10

Hyaluronan synthesis by in vitro cultured endolymphatic sac cells.

Amoils CP, Schindler RA, Parker DA, Hradek GT. Am J Otol. 1992 Jul;13(4):303-7. PMID: 1415490

The ELS and portions of the membranous labyrinth were dissected from whole otocyst specimens and placed in 14C glucose-enhanced tissue culture media. A light microscopic (LM), autoradiographic study was performed to assess whether 14C glucose could be incorporated b …