Covidin jälkeen fosfolipidien profiiliin tulee epätasapainoa. Lysofosfatidyyli-inositolia ja fosfatidyyli-inositolia tavallista enemmän, muita vähemmän

 Aiemmin ei ole huomiotani kiinnittänyt  lysofosfatidyyli-inositoli, joten otan siitä  tietoa esiin nyt.

The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis.

Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R. Hepatology. 2021 Feb;73(2):606-624. doi: 10.1002/hep.31290. Epub 2020 Nov 13. PMID: 32329085 Free PMC article.

BACKGROUND AND AIMS: G protein-coupled receptor (GPR) 55 is a putative cannabinoid receptor, and l-alpha-lysophosphatidylinositol (LPI) is its only known endogenous ligand. ...

2

Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors.

Irving A, Abdulrazzaq G, Chan SLF, Penman J, Harvey J, Alexander SPH. Adv Pharmacol. 2017;80:223-247. doi: 10.1016/bs.apha.2017.04.004. Epub 2017 Jun 12. PMID: 28826536 Review.

GPR18, GPR55, and GPR119 exhibit limited sequence homology with the established CB(1) and CB(2) cannabinoid receptors. However, the pharmacology of these orphan receptors displays overlap with CB(1) and CB(2) receptors, particularly for GPR18 and GPR55. ...Th …

3

GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity?

Nevalainen T, Irving AJ. Curr Top Med Chem. 2010;10(8):799-813. doi: 10.2174/156802610791164229. PMID: 20370712 Review.

However, to date, the most potent ligand identified for GPR55 is the endogenous phospholipid, lysophosphatidylinositol (LPI). GPR55 is thought to link predominantly G-protein alpha(13), where it promotes Rho-dependent signalling. ...This article reviews the current status …

4

Lysophosphatidylinositol, an Endogenous Ligand for G Protein-Coupled Receptor 55, Has Anti-inflammatory Effects in Cultured Microglia.

Minamihata T, Takano K, Moriyama M, Nakamura Y. Inflammation. 2020 Oct;43(5):1971-1987. doi: 10.1007/s10753-020-01271-4. PMID: 32519268

Lysophosphatidylinositol (LysoPI), an endogenous ligand for G protein-coupled receptor (GPR) 55, has been known to show various functions in several tissues and cells; however, its roles in the central nervous system (CNS) are not well known. ...

5

Druggable Lysophospholipid Signaling Pathways.

Yanagida K, Valentine WJ. Adv Exp Med Biol. 2020;1274:137-176. doi: 10.1007/978-3-030-50621-6_7. PMID: 32894510 Review.

Several crystal structures of LPA receptors and ATX have been solved, which will accelerate development of highly selective and effective LPA signaling targeting compounds. We also review additional bioactive lysophospholipid (LPL) signaling molecules including lysophospha …

6

Potential role and therapeutic interests of myo-inositol in metabolic diseases.

Croze ML, Soulage CO. Biochimie. 2013 Oct;95(10):1811-27. doi: 10.1016/j.biochi.2013.05.011. Epub 2013 Jun 10. PMID: 23764390 Review.

7

Minireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55.

Henstridge CM, Balenga NA, Kargl J, Andradas C, Brown AJ, Irving A, Sanchez C, Waldhoer M. Mol Endocrinol. 2011 Nov;25(11):1835-48. doi: 10.1210/me.2011-1197. Epub 2011 Sep 29. PMID: 21964594 Free PMC article. Review.

Emerging data suggest that off-target cannabinoid effects may be mediated via novel seven-transmembrane spanning/G protein-coupled receptors. Due to its cannabinoid sensitivity, the G protein-coupled receptor 55 (GPR55) was recently proposed as a candidate; however, …

8

Role of the lysophosphatidylinositol/GPR55 axis in cancer.

Falasca M, Ferro R. Adv Biol Regul. 2016 Jan;60:88-93. doi: 10.1016/j.jbior.2015.10.003. Epub 2015 Oct 28. PMID: 26588872 Review.

Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific …

9

Lysophosphatidylinositol Signalling and Metabolic Diseases.

Arifin SA, Falasca M. Metabolites. 2016 Jan 15;6(1):6. doi: 10.3390/metabo6010006. PMID: 26784247 Free PMC article. Review.

In this review, we will focus on the physiological and pathophysiological roles of the lysophospholipid mediator lysophosphatidylinositol (LPI) and its receptor G-protein coupled receptor 55 (GPR55) in metabolic diseases. ...

10

A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity.

Hurst K, Badgley C, Ellsworth T, Bell S, Friend L, Prince B, Welch J, Cowan Z, Williamson R, Lyon C, Anderson B, Poole B, Christensen M, McNeil M, Call J, Edwards JG. Hippocampus. 2017 Sep;27(9):985-998. doi: 10.1002/hipo.22747. Epub 2017 Jun 27. PMID: 28653801 Free PMC article.

GPR55, an orphan G-protein coupled receptor, is activated by lysophosphatidylinositol (LPI) and the endocannabinoid anandamide, as well as by other compounds including THC. ..