Entrez Gene Summary for TAC1 Gene
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This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
GeneCards Summary for TAC1 Gene
TAC1 (Tachykinin Precursor 1) is a Protein Coding gene. Diseases associated with TAC1 include Complex Regional Pain Syndrome and Vasomotor Rhinitis. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include substance P receptor binding.
UniProtKB/Swiss-Prot Summary for TAC1 Gene
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Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Aliases for TAC1 Gene
- GeneCards Symbol: TAC1 2
- Tachykinin Precursor 1 2 3 5
- NKNA 3 4 5
- TAC2 3 4 5
- NPK 2 3 5
- Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma) 2 3
- Neuropeptide Gamma 2 3
- Neurokinin Alpha 2 3
- Preprotachykinin 2 3
- Protachykinin-1 3 4
- Neuropeptide K 2 3
- Protachykinin 2 3
External Ids for TAC1 Gene
- HGNC: 11517
- NCBI Entrez Gene: 6863
- Ensembl: ENSG00000006128
- OMIM®: 162320
- UniProtKB/Swiss-Prot: P20366
Previous HGNC Symbols for TAC1 Gene
- TAC2
- NKNA
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