Löysin artikkelin josas puututaan tähän hyperfosforylaatioon Bricho chaperoni-terapialla.
katselin tri Samuel Cohenin you tube videon Cambridgesta . Se tuli kun selasin BACE1 entsyymiaihetta filmi filmiltä.
http://www.cam.ac.uk/research/news/molecular-inhibitor-breaks-cycle-that-leads-to-alzheimers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739963/
VIII. Protein Phosphatase-Directed Therapeutics for the Prevention and Treatment of Alzheimer’s Disease
According
to the National Institute on Aging, there are more than 5 million
Americans who suffer from AD. Yet, despite a desperate need, development
of an effective treatment for AD has been a major challenge. Four drugs
are currently approved by the FDA to treat cognitive deficits in AD.
Three of them are acetylcholinesterase inhibitors, which combat the loss
of acetylcholine caused by the death of cholinergic neurons, while the
other is a noncompetitive NMDA receptor antagonist, which inhibits
overactivation of NMDA receptors by glutamate.
1
None of these drugs halts progression of the disease. Significant
effort has been put into development of inhibitors of Aβ production.
233
However, targeting γ-secretase with nonselective γ-secretase inhibitors
has deleterious effects on health, likely because
γ-secretase also
cleaves other substrates, such as Notch, which are essential for normal
biological function.
234 This limitation is highlighted by the recent failure of the γ-secretase inhibitor
semagacestat in Phase III clinical trials.
235
Given the lack of available drugs to treat AD, it is imperative to
identify novel molecular processes that might be amenable to targeting
through new drugs. Protein phosphatases, including PP2A, and STEP may be
potential therapeutic targets for AD. It may also be possible to use a
strategy that would combine one or more regulator of a protein
phosphatase with kinase inhibitors that would provide a complementary
approach to control of, for example, hyperphosphorylation of tau.
PS: Kappale on pitkä ja siinä on paljon asiaa. hyperfosforylaatiossa on yksi seikka mitä voisi myös ottaa pinsettiin:
orgaanisen ja epäorgaanisen fosfaatin suhde kehossa, sillä siinäkin on moduloimisen varaa dietääriä tietä.- Tämä suhde on nykyaikana käänteinen verrattuna entisaikojen ravinnon aiheuttamaan fosfaattisuhtgeeseen.
