Fosfolipidit autofagosomin muodostuksessa ja fuusiossa

Volume 428, Issue 24, Part A, 4 December 2016, Pages 4819-4827

Review

Phospholipids in Autophagosome Formation and Fusion

Author links open overlay panelSaschaMartens¹

ShuheiNakamura²TamotsuYoshimori²

https://doi.org/10.1016/j.jmb.2016.10.029Get rights and content

Under a Creative Commons license

https://www.sciencedirect.com/science/article/pii/S0022283616304557

Highlights

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Phosphoinositides (PI)  regulate the initiation and elongation of isolation membranes.

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Lipids with small headgroups and, in particular, phosphatidylethanolamine (PE)  are likely to play important roles during autophagosome formation.

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The generation and specific turnover of phosphoinositides (PI) on autophagosomal and lysosomal membranes regulate fusion.

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The lipid composition of isolation membranes and autophagosomes is currently unknown.

 

Abstract

Autophagosomes are double-membrane organelles that are formed during a process referred to as macroautophagy. They serve to deliver cytoplasmic material into the lysosome for degradation. Autophagosomes are formed in a de novo manner and are the result of substantial membrane remodeling processes involving numerous protein–lipid interactions. While most studies focus on the proteins involved in autophagosome formation, it is obvious that lipids including phospholipids, sphingolipids, and sterols play an equally important role. Here, we summarize the current knowledge about the role of lipids, especially focusing on phospholipids and their interplay with the autophagic protein machinery during autophagosome formation and fusion.

Graphical Abstract

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