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måndag 27 april 2020

Fosfoinositideihin assosioitunut tukiproteiini GRASP, tamaliini

https://www.ncbi.nlm.nih.gov/pubmed/12586822/. telineproteiineja ()scaffoldprotein)  assosioitunut PI- fosfolipideihin.

2003 Apr 25;278(17):14762-8. Epub 2003 Feb 13.
Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association.
Official Symbol
TAMALIN
Official Full Name
trafficking regulator and scaffold protein tamalin
Also known as
GRASP
Summary
This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]
Expression
Broad expression in bone marrow (RPKM 8.3), fat (RPKM 7.8) and 23 other tissues See more
Orthologs
Preferred Names
general receptor for phosphoinositides 1-associated scaffold protein
Names
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
general receptor for phosphoinositides 1 associated scaffold protein
  1. NM_001271856.2NP_001258785.1  general receptor for phosphoinositides 1-associated scaffold protein isoform 2
    See identical proteins and their annotated locations for NP_001258785.1
    Status: REVIEWED
    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Conserved Domains (1) summary
    cd00992
    Location:942
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in proteases.
PDZ domain-containing protein (domain architecture ID 10097540)
PDZ domain-containing protein similar to Homo sapiens Tax1-binding protein 3, glutamate receptor-interacting protein 1, gamma-2-syntrophin, cytohesin-interacting protein, syntenin-1, and synaptojanin-2-binding protein.

What's a GeneRIF?

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