Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model.
Biomedicines. 2020 Sep 11;8(9):343. doi: 10.3390/biomedicines8090343.
PMID: 32932780
Free PMC article.
The Akita mice had a significant increase in hearing thresholds, blood glucose,
and insulin tolerance compared to WT mice. Histological analysis showed
that the loss of cells and damage to mitochondria in the spiral
ganglion neurons of Akita mice were significantly increas …
Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.
Biomed Res Int. 2018 Jun 14;2018:7817453. doi: 10.1155/2018/7817453. eCollection 2018.
PMID: 30013986
Free PMC article.
This study aimed to investigate the localization pattern of glucose
transporters (Gluts) in mouse cochlea. Genome-wide gene expression
analysis using CodeLink bioarrays indicated that Glut1 and Glut10 were
highly expressed (~10-fold) in mouse cochlea compared with the othe …
Differential localizations of the myo-inositol transporters HMIT and SMIT1 in the cochlear stria vascularis.
Neurosci Lett. 2018 May 1;674:88-93. doi: 10.1016/j.neulet.2018.03.028. Epub 2018 Mar 15.
PMID: 29551423
The cochlear stria vascularis produces endolymph
and thereby plays an active role in inner ear homeostasis. We recently
reported that the H(+)/myo-inositol cotransporter (HMIT) gene is
expressed in the stria vascularis. ...
The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion.
BMC Physiol. 2016 Aug 11;17(1):1. doi: 10.1186/s12899-016-0024-1.
PMID: 27515813
Free PMC article.
The acid flux was decreased to about 40 % of control by removal of the metabolic substrate (glucose-free)
and by inhibition of the sodium pump (ouabain). The flux was also
decreased a) by inhibition of Na,H-exchangers by amiloride,
dimethylamiloride (DMA), S3226 and Hoe694 …
Mitochondrial diabetes and deafness: possible dysfunction of strial marginal cells of the inner ear.
J Otolaryngol Head Neck Surg. 2011 Apr;40(2):93-103.
PMID: 21453644
Review.
One of our MIDD patients inspired us to propose an
integrated view on how a single mutation of the mitochondrial
deoxyribonucleic acid (DNA) affects both the glucose metabolism and the inner ear physiology. DESIGN: (a) Study of mitochondrial DNA in a patient with MIDD. (b) …
Cellular localization of facilitated glucose transporter 1 (GLUT-1) in the cochlear stria vascularis: its possible contribution to the transcellular glucose pathway.
Cell Tissue Res. 2008 Mar;331(3):763-9. doi: 10.1007/s00441-007-0495-2. Epub 2008 Jan 15.
PMID: 18196278
Immunoreactivity for the facilitated glucose
transporter 1 (GLUT-1) has been found in the cochlear stria vascularis,
but whether the strial marginal cells are immunopositive for GLUT-1
remains uncertain. ...The three-dimensional relationship between
marginal cells and basa …
The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene.
Am J Physiol Regul Integr Comp Physiol. 2002 Mar;282(3):R639-48. doi: 10.1152/ajpregu.00649.2001.
PMID: 11832382
Free article.
Review.
Like patients, knockout mice are deaf and show vestibular symptoms due to an impaired endolymph
production. Knockout mice show urinary and fecal salt wasting and
volume depletion. The renal phenotype is due to diminished reabsorption
of Na(+) and glucose. The mice a …
Effects of endolymphatic duct occlusion on the structure
and function of the endolymphatic sac in the adult guinea pig.
Laryngoscope. 1995 Feb;105(2):192-7. doi: 10.1288/00005537-199502000-00016.
PMID: 8544603
The present study was designed to determine the ELS
response to slower changes in fluid dynamics by occluding the
endolymphatic duct (ELD), thereby interrupting the longitudinal flow of endolymph to the ELS. Morphologic studies and autoradiographic techniques were used to …
Changes in hyaluronan synthesis by in vitro cultured endolymphatic sac cells.
Am J Otol. 1992 Jul;13(4):343-6.
PMID: 1415498
This model was chosen to determine whether a change in endolymph homeostasis affects ELS activity. Radiolabeled 14C glucose
incorporation was used to evaluate HA synthesis by ELS cells when
cultured in vitro. ...Therefore, the ELS cells of intact otocysts
incorporat …
Am J Otol. 1992 Jul;13(4):303-7.
PMID: 1415490
The ELS and portions of the membranous labyrinth were dissected from whole otocyst specimens and placed in 14C glucose-enhanced tissue culture media. A light microscopic (LM), autoradiographic study was performed to assess whether 14C glucose could be incorporated b …
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