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lördag 30 april 2016

Alfa-tokoferolifosfaatti säätelijänä

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Items: 1 to 20 of 83

1.
Modulation of Brain Glutathione Reductase and Peroxiredoxin 2 by α-Tocopheryl Phosphate.
Uchoa MF, de Souza LF, Dos Santos DB, Peres TV, Mello DF, Leal RB, Farina M, Dafre AL.
Cell Mol Neurobiol. 2016 Jan 9. [Epub ahead of print]
α-Tocopheryl phosphate (αTP) is a phosphorylated form of α-tocopherol. Since it is phosphorylated in the hydroxyl group that is essential for the antioxidant property of α-tocopherol, we hypothesized that αTP would modulate the antioxidant system, rather than being an antioxidant agent per se. α-TP demonstrated antioxidant activity in vitro against iron-induced oxidative stress in a mitochondria-enriched fraction preparation treated with 30 or 100 µM α-TP. However, this effect was not observed ex vivo with mitochondrial-enriched fraction from mice treated with an intracerebroventricular injection of 0.1 or 1 nmol/site of αTP. Two days after treatment (1 nmol/site αTP), peroxiredoxin 2 (Prx2) and glutathione reductase (GR) expression and GR activity were decreased in cerebral cortex and hippocampus. Glutathione content, glutathione peroxidase, and thioredoxin reductase activities were not affected by αTP. In conclusion, the persistent decrease in GR and Prx2 protein content is the first report of an in vivo effect of αTP on protein expression in the mouse brain, potentially associated to a novel and biologically relevant function of this naturally occurring compound.

KEYWORDS:

Antioxidant defense system; Glutathione reductase; Peroxiredoxin; Vitamin E; α-Tocopheryl phosphate
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2.
Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure.
Smith MT, Wyse BD, Edwards SR, El-Tamimy M, Gaetano G, Gavin P.
J Pharm Sci. 2015 Jul;104(7):2388-96. doi: 10.1002/jps.24502. Epub 2015 May 20.
PMID:
25995048
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3.
Induction of VEGF expression by alpha-tocopherol and alpha-tocopheryl phosphate via PI3Kγ/PKB and hTAP1/SEC14L2-mediated lipid exchange.
Zingg JM, Azzi A, Meydani M.
J Cell Biochem. 2015 Mar;116(3):398-407. doi: 10.1002/jcb.24988.
PMID:
25290554
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4.
Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate.
Yanamala N, Kapralov AA, Djukic M, Peterson J, Mao G, Klein-Seetharaman J, Stoyanovsky DA, Stursa J, Neuzil J, Kagan VE.
J Biol Chem. 2014 Nov 21;289(47):32488-98. doi: 10.1074/jbc.M114.601377. Epub 2014 Oct 2.
PMID:
25278024
Free PMC Article
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5.
α-Tocopheryl Phosphate as a Bioactive Derivative of Vitamin E: A Review of the Literature.
Ghayour-Mobarhan M, Saghiri Z, Ferns G, Sahebkar A.
J Diet Suppl. 2014 Sep 19. [Epub ahead of print]
PMID:
25238486
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6.
Modulation of phosphorylation of tocopherol and phosphatidylinositol by hTAP1/SEC14L2-mediated lipid exchange.
Zingg JM, Libinaki R, Meydani M, Azzi A.
PLoS One. 2014 Jul 1;9(7):e101550. doi: 10.1371/journal.pone.0101550. eCollection 2014.
PMID:
24983950
Free PMC Article
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7.
Role of hepatocyte growth factor in promoting the growth of human corneal endothelial cells stimulated by L-ascorbic acid 2-phosphate.
Kimoto M, Shima N, Yamaguchi M, Amano S, Yamagami S.
Invest Ophthalmol Vis Sci. 2012 Nov 9;53(12):7583-9. doi: 10.1167/iovs.12-10146.
PMID:
23081981
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8.
α-Tocopheryl-phosphate regulation of gene expression in preadipocytes and adipocytes.
Lirangi M, Meydani M, Zingg JM, Azzi A.
Biofactors. 2012 Nov-Dec;38(6):450-7. doi: 10.1002/biof.1051. Epub 2012 Oct 10.
PMID:
23047815
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9.
α-Tocopheryl phosphate--an activated form of vitamin E important for angiogenesis and vasculogenesis?
Zingg JM, Meydani M, Azzi A.
Biofactors. 2012 Jan-Feb;38(1):24-33. doi: 10.1002/biof.198. Epub 2012 Jan 27. Review.
PMID:
22281871
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10.
Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants.
Kato E, Sasaki Y, Takahashi N.
Bioorg Med Chem. 2011 Nov 1;19(21):6348-55. doi: 10.1016/j.bmc.2011.08.067. Epub 2011 Sep 5.
PMID:
21945458
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11.
α-tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.
Crouzin N, de Jesus Ferreira MC, Cohen-Solal C, M'Kadmi C, Bernad N, Martinez J, Barbanel G, Vignes M, Guiramand J.
Free Radic Biol Med. 2011 Nov 1;51(9):1643-55. doi: 10.1016/j.freeradbiomed.2011.07.012. Epub 2011 Aug 4.
PMID:
21843633
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12.
α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse.
Nishio K, Ishida N, Saito Y, Ogawa-Akazawa Y, Shichiri M, Yoshida Y, Hagihara Y, Noguchi N, Chirico J, Atkinson J, Niki E.
Free Radic Biol Med. 2011 Jun 15;50(12):1794-800. doi: 10.1016/j.freeradbiomed.2011.03.021. Epub 2011 Mar 26.
PMID:
21443945
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13.
Modulation of gene expression by α-tocopherol and α-tocopheryl phosphate in THP-1 monocytes.
Zingg JM, Libinaki R, Lai CQ, Meydani M, Gianello R, Ogru E, Azzi A.
Free Radic Biol Med. 2010 Dec 15;49(12):1989-2000. doi: 10.1016/j.freeradbiomed.2010.09.034. Epub 2010 Oct 26.
PMID:
20923704
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14.
alpha-Tocopherol enhances degranulation in RBL-2H3 mast cells.
Hemmerling J, Nell S, Kipp A, Schumann S, Deubel S, Haack M, Brigelius-Flohé R.
Mol Nutr Food Res. 2010 May;54(5):652-60. doi: 10.1002/mnfr.200900462.
PMID:
20169586
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15.
Analysis of vitamin E metabolites in biological specimen.
Birringer M.
Mol Nutr Food Res. 2010 May;54(5):588-98. doi: 10.1002/mnfr.200900457. Review.
PMID:
20169585
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16.
alpha-Tocopheryl phosphate--an active lipid mediator?
Zingg JM, Meydani M, Azzi A.
Mol Nutr Food Res. 2010 May;54(5):679-92. doi: 10.1002/mnfr.200900404. Review.
PMID:
20169583
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17.
Vitamin E and cancer.
Negis Y, Zingg JM, Libinaki R, Meydani M, Azzi A.
Nutr Cancer. 2009;61(6):875-8. doi: 10.1080/01635580903285197.
PMID:
20155629
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18.
alpha-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression.
Lobato KR, Cardoso CC, Binfaré RW, Budni J, Wagner CL, Brocardo PS, de Souza LF, Brocardo C, Flesch S, Freitas AE, Dafré AL, Rodrigues AL.
Behav Brain Res. 2010 Jun 19;209(2):249-59. doi: 10.1016/j.bbr.2010.02.002. Epub 2010 Feb 6.
PMID:
20144659
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19.
Effect of tocopheryl phosphate on key biomarkers of inflammation: Implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model.
Libinaki R, Tesanovic S, Heal A, Nikolovski B, Vinh A, Widdop RE, Gaspari TA, Devaraj S, Ogru E.
Clin Exp Pharmacol Physiol. 2010 May;37(5-6):587-92. doi: 10.1111/j.1440-1681.2010.05356.x. Epub 2010 Jan 17.
PMID:
20082629
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20.
alpha-tocopheryl phosphate suppresses tumor invasion concurrently with dynamic morphological changes and delocalization of cortactin from invadopodia.
Saitoh Y, Yumoto A, Miwa N.
Int J Oncol. 2009 Dec;35(6):1277-88.
PMID:
19885550
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