Väitöskirja PI3-kinaasista ja ARAP2. Mikä on ARAP2

On esitteillä uusi väitöskirjan. otsikko on   Roles of PI3K and ARAP2 in regulating glucose metabolism.
Väittelijä on Aditi Chaudhari. Vastaväittäjä on Sveitsistä  professori Matthias Wymann.
Väitöstilaisuus on edessäpäin ja tässä katson alustavasti abstraktin sanomaa.

Eninnäkin  ARAP2 geenin  nimen tarkistus on tästä lähteestä:
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ARAP2

ARAP2 geenillå  on  synonyymejä, joista sen tuntee: Centaurin Delta 1,Cnt-D1, CENTD1, Arf And Rho GAD Adapter protein 2,protein PARX, KIAA0580, PARX.
ARAP2 = Ankyrin Repeat AND PH Doman 2.
ARAP2 geeni sijaitsee kromosomissa 4p14(15.1)

Näistä ArfGAP-proteiineista on hyvä luettelo netissä syöpätutkimusten yhteydessä tästä lätheestä saa myös ARAP2 proteiinin sijoittumisen näitten joukkoon. 

ArfGAP-perhe   http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0854.2007.00624.x/pdf 2007 

• Review Arf GAPs and Their Interacting Proteins Hiroki Inoue and Paul A. Randazzo* Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA Membrane trafficking and remodeling of the actin cyto-
• skeleton are critical activities contributing to cellular
  events that include cell growth, migration and tumor
  invasion. ADP-ribosylation factor (Arf)-directed GTPase
  activating proteins (GAPs) have crucial roles in these
  processes. The Arf GAPs function in part by regulating
  hydrolysis of GTP bound to Arf proteins. The Arf GAPs,
  which have multiple functional domains, also affect the
  actin cytoskeleton and membranes by specific interac-
  tions with lipids and proteins. A description of these
  interactions provides insights into the molecular mecha-
  nisms by which Arf GAPs regulate physiological and
  pathological cellular events. Here we describe the Arf
  GAP family and summarize the currently identified
  protein interactors in the context of known Arf GAP
  functions.
  Key words: actin, Arf1, Arf6, ASAP1, circular dorsal
  ruffles, cortactin, EGF receptor, focal adhesion, invado-
  podia, podosome
  Received 10 May 2007, revised and accepted for publica-
  tion 6 July 2007, uncorrected manuscript published
  online 12 July 2007, published online 31 July 2007
  • ARAP21 on suurin proteiini näissä ArfGAP-perheen proteiineissa 
    ARAPs are the largest proteins in the Arf GAP family. GAPs in this subtype have
     a Rho GAP domain in addition to an ArfGAP domain. They also contain a sterile
    a-motif (SAM), five PH domains and a Ras association (RA) domain. Two
    of the five PH domains contain a PI(3,4,5)P3-binding con-sensus 
    sequence. PI(3,4,5)P3 more potently stimulates the Arf GAP activity of ARAPs 
    than do other  phosphoinositides . The three members of the ARAP subtype of
    Arf GAPs have different Arf specificities. ARAP1 (centaurin d1
    functions with Arf1 and Arf5 .  ARAP2 (centaurin d1 PARX
     preferentially uses Arf6, as compared with Arf1 and Arf5, as a substrate
    in vitro and in vivo . ARAP3 (DRAG/ centaurin d  has been reported to function as an Arf6 or Arf5 GAP in vitro and to regulate Arf6-dependent events including membrane protrusions and ruffling
    in vivo.