WIPI3, WDR46B, (17q25.3), NEDSBAS , beeta-propellirakenteinen autofagian kotrolloija

https://www.ncbi.nlm.nih.gov/gene/56270

Official Symbol

WDR45Bprovided by HGNC

Official Full Name

WD repeat domain 45Bprovided by HGNC

Also known as

WIPI3; WDR45L; WIPI-3; NEDSBAS

Summary

This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]

Expression

Ubiquitous expression in testis (RPKM 30.3), esophagus (RPKM 20.3) and 25 other tissues See more

Orthologsmouse all

Preferred Names

WD repeat domain phosphoinositide-interacting protein 3

Names

WD repeat protein 45-like

WD repeat-containing protein 45-like

WD repeat-containing protein 45B

WDR45-like protein

WIPI3 long

WIPI49-like protein

 https://www.ncbi.nlm.nih.gov/protein/NP_062559.2

ORIGIN      
        1 mnllpcnphg ngllyagfnq dhgcfacgme ngfrvyntdp lkekekqefl eggvghveml
       61 frcnylalvg ggkkpkyppn kvmiwddlkk ktvieiefst evkavklrrd rivvvldsmi
      121 kvftfthnph qlhvfetcyn pkglcvlcpn snnsllafpg thtghvqlvd lastekppvd
      181 ipahegvlsc ialnlqgtri atasekgtli rifdtssghl iqelrrgsqa aniycinfnq
      241 daslicvssd hgtvhifaae dpkrnkqssl asasflpkyf sskwsfskfq vpsgspcica
      301 fgtepnavia icadgsyykf lfnpkgecir dvyaqflemt ddkl
//

Related articles in PubMed

1. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Jeffries TR, et al. Mol Biol Cell, 2004 Jun. PMID 15020712, Free PMC Article
2. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. Proikas-Cezanne T, et al. Oncogene, 2004 Dec 16. PMID 15602573
3. WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. Bakula D, et al. Nat Commun, 2017 May 31. PMID 28561066, Free PMC Article
4. Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Raman M, et al. Nat Cell Biol, 2015 Oct. PMID 26389662, Free PMC Article
5. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. WIPI3 and WIPI4 beta-propellers have roles as scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

Submit: New GeneRIF Correction