IPP-syntaasi 1 (PPIP5K1 geeni)

PPIP5K1 geeni, kromosomi 15q15.3

Synonyyminimet: HISPPD2A ( histidiinihappofosfataasidomaanin sisältävä proteiini 2A )

IP6K-perhe, IP6-kinaasiperhe

IPS1, inositol pyrophosphate synthase 1 , IPP syntaasi 1

VIP1

hsVIP1

Tämä proteiini omaa kaksoisfunktion ( dual functional inositolkinase)

Ensin se fosforyloi IP6- muodon PP-IP5 muotoon., siis IP7-muotoon.

Sitten se fosforyloi PP-IP5- muodon (PP)2-IP4 muotoon, siis IP8 muotoon. 

Geenituoteta aktivoi solun  hyperosmoottinen stressi. 

LÄHDE:

https://www.ncbi.nlm.nih.gov/gene/9677

PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 [ Homo sapiens (human) ]

Gene ID: 9677, updated on 19-Jan-2017

Summary

Official Symbol

PPIP5K1provided by HGNC

Official Full Name

diphosphoinositol pentakisphosphate kinase 1provided by HGNC

Primary source

HGNC:HGNC:29023

See related

Ensembl:ENSG00000168781 MIM:610979; Vega:OTTHUMG00000059758

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

IP6K; IPS1; VIP1; hsVIP1; HISPPD2A

Summary

This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010

Tästä on muutamia uusia artikkeleita:

Related articles in PubMed

1. PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility. Machkalyan G, et al. Cell Signal, 2016 May. PMID 26854614
2. Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. Gokhale NA, et al. Biochem J, 2011 Mar 15. PMID 21222653, Free PMC Article
3. Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. Choi JH, et al. J Biol Chem, 2007 Oct 19. PMID 17702752, Free PMC Article
4. Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. Lin H, et al. J Biol Chem, 2009 Jan 16. PMID 18981179, Free PMC Article
5. Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. Fridy PC, et al. J Biol Chem, 2007 Oct 19. PMID 17690096
   

See all (16) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. results suggest that PPIP5K1 might play an important role in regulating function of exocyst complex in establishing cellular polarity and directional migration of cells
2. Upon activation of the appropriate cell-surface receptors to stimulate PtdIns(3,4,5)P3 synthesis, human PPIP5K1 translocates from the cytoplasm to the plasma membrane.
   

Muistiin 24.1. 2017