Inositolipolyfosfaattien metaboliasta Avustusta HCV ja SARS-2 koronaviruksen viruksen replikaatio-organellin luomiseen.

 

https://pubmed.ncbi.nlm.nih.gov/27701417/

https://pubmed.ncbi.nlm.nih.gov/23107997/

https://pubmed.ncbi.nlm.nih.gov/24152294

The enzymes of human diphosphoinositol polyphosphate metabolism

https://pubmed.ncbi.nlm.nih.gov/10777568/

. 2000 Apr 28;275(17):12730-6.

doi: 10.1074/jbc.275.17.12730.

Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family

 

https://www.pnas.org/doi/full/10.1073/pnas.1922284117 

InsP₇ is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics

 Article| Volume 37, ISSUE 8, 110049, November 23, 2021:

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•  Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation

• Woan-Ing Twu

Open AccessPublished:November 09, 2021DOI:https://doi.org/10.1016/j.celrep.2021.110049

 

(Kommentti: Artikkeli mainitsee proteiinifosfataasin, jolla on FYVEdomeeni,  ZFYVE1 alias   tekijän  DFCP1 , joka osallistuu  viruksen  replikaatio-organellin (Double Membrane vesicles) tekoon.   Tässä on apuna Class III PI3K kompleksi ja sen tuote PI3P-lipidi.

Toisesta lähteestä (2020 )   on tieto, että  Sars-Cov-2 nsp 13 rekrytoi  myös ZFYVE7. Se on toiselta nimeltä  FYCO1. 

 

Artikkeli ennen Sars-2 aikaa vuodelta 2010 FYCo1 funktiosta :   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812517/  

 

 Autophagy is the main eukaryotic degradation pathway for long-lived proteins, protein aggregates, and cytosolic organelles. Although the protein machinery involved in the biogenesis of autophagic vesicles is well described, very little is known about the mechanism of cytosolic transport of autophagosomes. In this study, we have identified an adaptor protein complex, formed by the two autophagic membrane-associated proteins LC3 and Rab7 and the novel FYVE and coiled-coil (CC) domain–containing protein FYCO1, that promotes microtubule (MT) plus end–directed transport of autophagic vesicles. We have characterized the LC3-, Rab7-, and phosphatidylinositol-3-phosphate–binding domains in FYCO1 and mapped part of the CC region essential for MT plus end–directed transport. We also propose a mechanism for selective autophagosomal membrane recruitment of FYCO1.   

 

(Huom: Virukset HCV ja Sars-cov2 eivät kuitenkaan johda autofagiakompleksin tekoon, vaan  fagoforivaiheesta  sulkeutuvaan kaksoisrakkulaan (DMV), joka on replikaatio-organelli näille viruksille).