https://www.sciencedirect.com/topics/nursing-and-health-professions/tachykinin
Tachykinin
Tachykinins (meaning fast acting) are characterized by an amidated C-terminus containing the amino acids F-X-G-L-M-NH2, where X is a hydrophobic amino acid residue.
From: Encyclopedia of Biological Chemistry (Second Edition), 2013
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KININS AND NEUROPEPTIDES | Tachykinins
G.F. Joos, K. De Swert, in Encyclopedia of Respiratory Medicine, 2006
Immunomodulation
Tachykinins are known to have a wide variety of modulatory effects on inflammatory and immune cells. Substance P degranulates mast cells, leading to the release of histamine and 5-hydroxytryptamine (5-HT, serotonin), and the production of tumor necrosis factor alpha (TNF-α). Tachykinins cause adherence and chemotaxis of human neutrophils. Substance P induces chemotaxis of human eosinophils. Several in vitro and in vivo studies have shown that substance P is able to modulate the chemotaxis, proliferation, and activation of lymphocytes. Tachykinins also have a number of stimulatory effects on monocytes and macrophages: substance P has been shown to evoke superoxide anion production, enhance phagocytosis, and cause production of interleukin-1 and interleukin-12 by macrophages. Tachykinins are also able to activate mesenchymal cells in the airways.
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