TAC4(17q21.33) Takykiniini-4, Hemokiniini, josta ei vielä tiedetä tarkalleen vaikutuksia. Toimii TACR1-ligandina.

 Tällä takykiniini-4, hemokiniinillä, on muista takykiniineistä poikkeava vaikutus ja sen merkitystä ei  vielä täysin tiedetä. Se toimii ensisijaisesti  reseptorin TACR1 ligandina.

Entrez Gene Summary for TAC4 Gene

• This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAC4 Gene

TAC4 (Tachykinin Precursor 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

 Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior

Aliases for TAC4 Gene

• GeneCards Symbol: TAC4 ²
• Tachykinin Precursor 4 ^{2 3 5}
• PPT-C ^{2 3 4 5}
• HK-1 ^{2 3 5}
• Preprotachykinin-C ^{3 4}
• Tachykinin-4 ^{3 4}
• Pptc ^{2 5}

• Tachykinin 4 (Hemokinin) ³
• Tachykinin 4 ²
• Hemokinin ²
• Endokinin ³
• HK1 ³
• EK ³