TACR1 geeni (2p12). Substanssi-P reseptori liittyy G-proteiinilla aktivoituvaan PI/Ca sekundääriseen välittäjäainejärjestelmään

 https://www.genecards.org/cgi-bin/carddisp.pl?gene=TACR1&keywords=Tachykinin

 

Aliases for TACR1 Gene

• GeneCards Symbol: TACR1 ²
• Tachykinin Receptor 1 ^{2 3 4 5}
• NK1R ^{2 3 4 5}
• SPR ^{2 3 4 5}
• Substance-P Receptor ^{2 3 4}
• TAC1R ^{3 4 5}

• NKIR ^{2 3 5}
• Neurokinin Receptor 1 ^{2 3}
• NK-1 Receptor ^{3 4}
• NK-1R ^{3 4}
• Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor) ³

Entrez Gene Summary for TACR1 Gene

• This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

GeneCards Summary for TACR1 Gene

TACR1 (Tachykinin Receptor 1) is a Protein Coding gene. Diseases associated with TACR1 include Cystitis and Causalgia. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and substance P receptor activity. An important paralog of this gene is TACR3.

UniProtKB/Swiss-Prot Summary for TACR1 Gene

• This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

  • NK1R_HUMAN,P25103

Tocris Summary for TACR1 Gene

• The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum and amygdala) and peripheral tissues.