Kiinnostava FYVE domeeni. Myös TP53 omaa FYVE-domeenin.

https://www.ncbi.nlm.nih.gov/gene/7157
 TP53    (Kr.17p13.1) , p53

Also known as  P53; BCC7; LFS1; TRP53

 

Summary  This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Expression Ubiquitous expression in spleen (RPKM 13.2), lymph node (RPKM 13.1) and 25 other tissues See more Orthologs  mouse all

Preferred Names

cellular tumor antigen p53

Names

antigen NY-CO-13

mutant tumor protein 53

p53 tumor suppressor

phosphoprotein p53

transformation-related protein 53

tumor protein 53

tumor supressor p53

Conserved Domains (3) summary

pfam00870
Location:95 → 289

P53; P53 DNA-binding domain

pfam07710
Location:319 → 358

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:5 → 28

P53_TAD; P53 transactivation motif

(Vaikuttaa olevan kaksi FYVE- jaksoa)

Peptide sequence and history https://www.ncbi.nlm.nih.gov/protein/NP_000537.3 ORIGIN

        1 meepqsdpsv epplsqetfs dlwkllpenn vlsplpsqam ddlmlspddi eqwftedpgp
       61 deaprmpeaa ppvapapaap tpaapapaps wplsssvpsq ktyqgsygfr lgflhsgtak
      121 svtctyspal nkmfcqlakt cpvqlwvdst pppgtrvram aiykqsqhmt evvrrcphhe
      181 rcsdsdglap pqhlirvegn lrveylddrn tfrhsvvvpy eppevgsdct tihynymcns
      241 scmggmnrrp iltiitleds sgnllgrnsf evrvcacpgr drrteeenlr kkgephhelp
      301 pgstkralpn ntssspqpkk kpldgeyftl qirgrerfem frelnealel kdaqagkepg
      361 gsrahsshlk skkgqstsrh kklmfktegp dsd