MTMR FOSFATAASEJA ON ISO PERHE.
(MTMR3 omaa FYVE domaanitkin . katson sen tunnetut ja suositellut nimet)
Otan tästä lähdetietoa. ihmiselläkin on niitä 14 proteiinia ja niistä kahdeksan ovat katalyyttiseti aktiivea fosfataasena ja kuusi katalyyttisesti inaktiivia. Aktiiveilla MTMR-jäsenillä on kaikilla fosfataasiaktiivisuutta PI3P ja PI(3,5)P2 fosfoinositidilajeja kohtaan. (Tässä käytetään uutta termiäkin pylofosfoinositidit, PPIn) - ja tämä spesifisyys viittaisi intrasellulaariseen liikenteeseen ja kalvohomeostaasiin. MTMR- lyhennys tarkoitta Myotubulariinin liittyvien fosfolipidien fosfataasi
Mol Neurobiol. 2007 Jun;35(3):308-16.
Myotubularin-related (MTMR) phospholipid phosphatase proteins in the peripheral nervous system. Bolis A1, Zordan P, Coviello S, Bolino A. Abstract Myotubularin-related proteins (MTMRs) constitute a broad family of ubiquitously expressed phosphatases with 14 members in humans, of which eight are catalytically active phosphatases, while six are catalytically inactive. Active MTMRs possess 3-phosphatase activity toward both PtdIns3P and PtdIns(3, 5)P 2 poliphosphoinositides (PPIn), suggesting an involvement in intracellular trafficking and membrane homeostasis.
Näitten MTMR- fosfataasien joukossa MTMR2 ja MTMR13 eivät kata toistensa funktioita hermossa. Jommankumman puute aiheuttaa CMT tyyppi 4B1 ja B2 neuropatiat vastaavasti. Tyypillistä on demyelinaatio ja poikkeukselliset myeliinipoimut.
MTMR2 fosfolipidifosfataasi sattaa säädellä kalvohomeostaasissa taaphtumia Schwannin soluissa hermon postnataalin kehittymisen aiakna. Artikkeli valaisee lähinnä MTMR2 ja MTMR13 kannalta näitä MTMR perheen jsäeniä. solunsisäisiä
MTMR2 fosfolipidifosfataasi sattaa säädellä kalvohomeostaasissa taaphtumia Schwannin soluissa hermon postnataalin kehittymisen aiakna. Artikkeli valaisee lähinnä MTMR2 ja MTMR13 kannalta näitä MTMR perheen jsäeniä. solunsisäisiä
- Among MTMRs, catalytically active MTMR2 and inactive MTMR13 have a nonredundant function in nerve. Loss of either MTMR2 or MTMR13 causes Charcot-Marie-Tooth type 4B1 and B2 neuropathy, respectively, characterized by demyelination and redundant loops of myelin known as myelin outfoldings. In Mtmr2-null mouse nerves, these aberrant foldings occur at 3-4 weeks after birth, a time when myelination is established, and Schwann cells are still elongating to reach the final internodal length. Moreover, Mtmr2-specific ablation in Schwann cells is both sufficient and necessary to provoke CMT4B1 with myelin outfoldings. MTMR2 phospholipid phosphatase might regulate intracellular trafficking events and membrane homeostasis in Schwann cells during postnatal nerve development. In this review, we will discuss recent findings on the MTMR family with a major focus on MTMR2 and MTMR13 and their putative role in Schwann cell biology.
- PMID:
- 17917119
- [Indexed for MEDLINE]
- MTMR3 on ZFYVE10
- Also known as ZFYVE10; FYVE-DSP1
- Summary This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in bone marrow (RPKM 20.3), testis (RPKM 13.1) and 25 other tissues See more Orthologs mouse all
Related articles in PubMed
- Myotubularin-related phosphatase 3 promotes growth of colorectal cancer cells. Zheng B, et al. ScientificWorldJournal, 2014. PMID 25215329, Free PMC Article
- Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3. Son JY, et al. Acta Crystallogr F Struct Biol Commun, 2014 Sep. PMID 25195900, Free PMC Article
- Brief Report: identification of MTMR3 as a novel susceptibility gene for lupus nephritis in northern Han Chinese by shared-gene analysis with IgA nephropathy. Zhou XJ, et al. Arthritis Rheumatol, 2014 Oct. PMID 24943867, Free PMC Article
- Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Taguchi-Atarashi N, et al. Traffic, 2010 Apr. PMID 20059746
- Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3. Lorenzo O, et al. J Cell Sci, 2005 May 1. PMID 15840652
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
- Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus.
- the rs713875 IBD risk polymorphism increases MTMR3 expression, which modulates pattern recognition receptor (PRR)-induced outcomes, including increased induced caspase-1 activation
- myotubularin-related protein 3 and myotubularin-related protein 4 may act as a bridge between CEP55 and polo-like kinase 1, ensuring proper CEP55 phosphorylation and regulating CEP55 recruitment to the midbody.
- cloning, expression, purification and crystallization of human myotubularin-related protein 3 encompassing the PH-GRAM and the phosphatase catalytic domain are reported
- These results indicate that MTMR3 may play an important role in the progression of CRC and suggest that siRNA mediated silencing of MTMR3 could be an effective tool in CRC treatment.
- Our results suggest that the MTMR3 gene is shared between IgA nephropathy and lupus nephritis in the northern Chinese population, further highlighting the role of autophagy in systemic lupus erythematosus.
- Data suggest MTMR3, PIKFYVE (phosphoinositide kinase FYVE), and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein); this process regulates migration/invasion of carcinoma/sarcoma.
- Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration.
- A phylogenetic study revealing co-evolution of myotubularins with PI 3-kinase class III complex
- MTMR3 shares similar phosphatase activity and substrate specificity with its homologous proteins MTM1 and MTMR3
MTMR3 Preferred Names
- myotubularin-related protein 3
- Names
- FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase
- FYVE domain-containing dual specificity protein phosphatase 1
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase
- phosphatidylinositol-3-phosphate phosphatase
- zinc finger FYVE domain-containing protein 10
- zinc finger, FYVE domain containing 10
- NP_694690.1..
Conserved Domains (3) summary
-
- cd13341
Location:23 → 116 - PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
- cd15732
Location:1115 → 1175 - FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
- pfam06602
Location:127 → 523 - Myotub-related; Myotubularin-like phosphatase domain
- cd13341
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