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tisdag 18 oktober 2022

Perustava molekyyli PLASMINOGEENI (PLG) omaa kaksi glykoformia ihmisessä Tyyppi I ja Tyyppi II

 https://diapharma.com/plasminogen-plg/

Sitaatti 18.10.2022: 

"Plasminogen (PLG)

Plasmin is released as a zymogen called plasminogen (PLG) from the liver into the factor IX systemic circulation. Two major glycoforms of plasminogen are present in humans – type I plasminogen contains two glycosylation moieties (N-linked to N289 and O-linked to T346), whereas type II plasminogen contains only a single O-linked sugar (O-linked to T346). Type II plasminogen is preferentially recruited to the cell surface over the type I glycoform. Conversely, type I plasminogen appears more readily recruited to blood clots."

(Tässä lähteessä kaavat Plasminogeeni, sen aktivaattorit   t-PA kudosaktivaattori ja  munuaisperäinen u-PA) .

 

 

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