Centaurin, alfa-1, ADAP-1

http://en.wikipedia.org/wiki/Centaurin,_alpha_1 (Wikipedia)
 Kentauriini alfa 1  on kaksoisreseptori , se tunnistaa IP4 ja   PIP3  molekyylit, joihin se kiinnittyy.
Kentauriini alfa 1 proteiinia  koodaa geeni ADAP1  kromosomissa 7  ihmisellä. Se on moitokondriaalinen ja destabilisoi mitokondrian aiheutaen  apoptoosia.

Centaurin, alpha 1 (kuva netistä)  Päivitys 2.2. 2015

ArfGAP with dual PH domains 1
Available structures PDB Ortholog search: PDBe, RCSB [show]List of PDB id codes
Identifiers
Symbols	ADAP1 ; CENTA1; GCS1L; p42IP4
External IDs	OMIM: 608114 MGI: 2442201 HomoloGene: 55997 GeneCards: ADAP1 Gene

Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene.^[1][2]
Centaurin, alpha 1 has been shown to interact with Protein kinase D1,^[3] Nucleolin,^[4] PRKCI,^[3] P110α,^[3] Casein kinase 1, alpha 1^[5][6] and Protein kinase Mζ.^[3]
References (Kts. Wikipediasta)

1. "Entrez Gene: CENTA1 centaurin, alpha 1".
2. Dubois, Thierry; Zemlickova Eva; Howell Steven; Aitken Alastair (Feb 2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochem. Biophys. Res. Commun. (United States) 301 (2): 502–8. doi:10.1016/S0006-291X(02)03010-3. ISSN 0006-291X. PMID 12565890.

• Whitley P, Gibbard AM, Koumanov F, et al. (2003). "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.". Eur. J. Cell Biol. 81 (4): 222–30. doi:10.1078/0171-9335-00242. PMID 12018390.
• Reiser G, Bernstein HG (2003). "Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha.". Neuroreport 13 (18): 2417–9. doi:10.1097/01.wnr.0000048005.96487.10. PMID 12499840.
• Venkateswarlu K, Brandom KG, Lawrence JL (2004). "Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization.". J. Biol. Chem. 279 (8): 6205–8. doi:10.1074/jbc.C300482200. PMID 14625293.