IP6( fytiini) on BACE 1 inhibiittori

http://www.ncbi.nlm.nih.gov/pubmed/24649396
On tunnistettu, että fytiini(IP6) vaikuttaa  beta-sekretaasiin(BACE 1)  estävästi.  Alzheimerin taudissa  akkumuloituu Abeeta tuotetta aivoihin.  Abeeta tulee sAPP proteiinista  beeta-sekretaasin  ja gamma-sekretaasin aiheuttamalla pilkkoutumisella   Fytiini pystyi estämään  beetasekretaasin aiheuttamaa pilkkoutumistapaa. ja täten  abeetan akkumuloitumista.
Tämän tutkimuksen  fytiini oli riisinjyvistä  valmistettua.  Tästä voidaan kehitellä  uutta lääkeaine ja / tai dieettiperiaatetta AD taudin estoon.

FEBS Open Bio. 2014 Jan 31;4:162-7. doi: 10.1016/j.fob.2014.01.008. eCollection 2014. 

Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE1) inhibitory molecule in rice grain extract and digest.

Abe TK, Taniguchi M.

Author information

Abstract

Alzheimer's disease (AD) is widely considered to be caused by amyloid-β peptide (Aβ) accumulation in the brain. Aβ is excised from amyloid-β precursor protein through sequential cleavage by β-secretase 1 (BACE1) and γ-secretase. Thus, BACE1 inhibition could prevent Aβ accumulation. Here, we identified myo-inositol hexakisphosphate (IP6) as a BACE1 inhibitory molecule in rice grain extract and digest. The rice digest and IP6 significantly inhibited Aβ production in neuroblastoma cells without cytotoxicity. These results suggested that rice components, including IP6, may be promising starting materials for the development of potent and safe drugs and/or food to prevent AD.

KEYWORDS:

AD, Alzheimer’s disease; APP, amyloid-β precursor protein; Alzheimer’s disease; Aβ; Aβ, amyloid-β peptide; BACE1; BACE1, β-secretase 1/beta-site APP cleaving enzyme 1; IC50, half-maximal inhibitory concentration; IP6; IP6 (PS), phytic acid dipotassium salt; IP6 (SS), phytic acid sodium salt; IP6, myo-inositol hexakisphosphate/phytic acid; Rice grain; SH-SY5Y cells; β-CTF, C-terminal fragment of β-cleaved APP

PMID:

24649396

[PubMed]

PMCID:

PMC3953730

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