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torsdag 29 november 2018

NUDT12(5q21.2) Peroxisomal NADH pyrophosphatase

Summary
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in kidney (RPKM 12.0), thyroid (RPKM 10.7) and 24 other tissues See more

Orthologs
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Preferred Names
peroxisomal NADH pyrophosphatase NUDT12
Names
nucleoside diphosphate linked moiety X-type motif 12
nucleoside diphosphate-linked moiety X motif 12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
nudix motif 12
NP_001287670.1
Structure, History

Conserved Domains (6) summary
COG2816
Location:108437
NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
cd00204
Location:1480
ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
cd03429
Location:305438
NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
pfam09296
Location:130259
NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
pfam09297
Location:261284
zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
pfam12796
Location:1680
Ank_2; Ankyrin repeats (3 copies)

Related articles in PubMed

GeneRIFs: Gene References Into Functions


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