NUDT8 (11q13.2) ( CoAse domain)

https://www.ncbi.nlm.nih.gov/gene/254552
VALIDATED 

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Expression

Broad expression in kidney (RPKM 5.4), heart (RPKM 4.8) and 25 other tissues See more

Orthologs mouse all

 Structure, History : 
 
NM_001243750.2 → NP_001230679.1  nucleoside diphosphate-linked moiety X motif 8 isoform 1
aminoacids 32..186, CoAse
aminoacids 69..92, Nudix motif   ( k cdpadqdvvh talretreel glavpeehvw gl)
aminoacids 70..91 Nudix box  ( h talretreel glavpeehvw g)
a.a. 70, N-succinyl-lysine (k) 
a.a. 85, metal binding site (e)

ORIGIN      
        1 mlpdclsaeg elrcrrllag atarlrarpa saavlvplcs vrgvpallyt lrssrltgrh
       61 kgdvsfpggk cdpadqdvvh talretreel glavpeehvw gllrpvydpq katvvpvlag
      121 vgpldpqslr pnseevdevf alplahllqt qnqgythfcr gghfrytlpv flhgphrvwg
      181 ltavitefal qllapgtyqp rlagltcsga eglarpkqpl aspcqasstp glnkgl

Related articles in PubMed

1. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Gasmi L, et al. Biochem J, 2001 Jul 1. PMID 11415433, Free PMC Article
2. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Floyd BJ, et al. Mol Cell, 2016 Aug 18. PMID 27499296, Free PMC Article
3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791.  One hundred and thirty-seven genes were identified as being either up- or down-regulated in human ICC cells.
4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624, Free PMC Article
5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (9) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Observational study of gene-disease association. (HuGE Navigator)