Phytin Fytiini: NUDT7 (16q23.1), Peroxisomal CoA diphosphatase (CoAse)

torsdag 29 november 2018

https://www.ncbi.nlm.nih.gov/gene/283927


Summary: The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression: Ubiquitous expression in liver (RPKM 10.5), heart (RPKM 9.9) and 24 other tissues See more
Orthologs: mouse all

Preferred Names: peroxisomal coenzyme A diphosphatase NUDT7

 Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population

Conserved Domains (1) summary

cd03426 Location:41 → 201: CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid synthesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids (LCFA) in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.

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