NUDT9 (4q22.1) , ADPR-PPase , mitokondriaalinen

Also known as

NUDT10

Summary

The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Expression

Ubiquitous expression in kidney (RPKM 6.8), prostate (RPKM 6.3) and 25 other tissues See more

Orthologs mouse all

 

Preferred Names

ADP-ribose pyrophosphatase, mitochondrial

Names

ADP-ribose diphosphatase

ADP-ribose phosphohydrolase

ADP-ribose pyrosphosphatase NUDT9

ADPR-PPase

adenosine diphosphoribose pyrophosphatase

nucleoside diphosphate linked moiety X-type motif 9

nudix (nucleoside diphosphate linked moiety X)-type motif 9

NP_001234940.1

• EC 3.6.1.13

  Structure, History,

NM_001248011.1 → NP_001234940.1  ADP-ribose pyrophosphatase, mitochondrial isoform c precursor

 https://www.ncbi.nlm.nih.gov/protein/NP_001234940.1

Related articles in PubMed

1. Differential expression of NUDT9 at different phases of the menstrual cycle and in different components of normal and neoplastic human endometrium. Chen LY, et al. Taiwan J Obstet Gynecol, 2009 Jun. PMID 19574167.NUDT9 is known to function as a highly specific adenosine diphosphate ribose pyrophosphatase and has been mapped to chromosome 4q22.1. It gives rise to two alternatively spliced messenger RNAs, NUDT9alpha and NUDT9beta, encoding a member of the Nudix hydrolase family. In this study, we purified NUDT9 protein and produced an antibody, which we then used for immunohistochemical studies.Using this anti-NUDT9 antibody, we successfully demonstrated that NUDT9 protein was differentially expressed in endometrial glandular cells at different phases of the menstrual cycle. NUDT9 was also found to be expressed more prominently in the epithelial glandular component than in the stromal component of human endometrial carcinomas.We suggest that NUDT9 may be involved in the regulation of the menstrual cycle and may be related to the proliferation of glandular cells in the human endometrium.
2. The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. Carloto A, et al. Biochim Biophys Acta, 2006 Oct. PMID 16860484
3. The crystal structure and mutational analysis of human NUDT9. Shen BW, et al. J Mol Biol, 2003 Sep 12. PMID 12948489
4. Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method. Zhang HT, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Aug. PMID 12897971
5. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. Perraud AL, et al. J Biol Chem, 2003 Jan 17. PMID 12427752

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. NUDT9 may be involved in the regulation of the menstrual cycle and may be related to the proliferation of glandular cells in the human endometrium
2. parallel enzymic characterization of the specific ADP-ribose pyrophosphatase from human placenta and a recombinant NUDT9 protein expressed from a cDNA clone was carried out
3. Data report the crystal structures of NUDT9 in the presence and in the absence of the reaction product ribose 5'-phosphate.
4. analysis of the human NUDT9 gene and its potential alternative transcripts along with detailed studies of the enzymatic properties and cell biological behavior of human NUDT9 protein
5. Hydrolyses ADP-ribose to AMP and ribose-5-phosphate

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