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torsdag 29 november 2018

NUDT18 (8p21.3), 8-oxo-dGDP phosphatase, MTH3

https://www.ncbi.nlm.nih.gov/gene/79873
MTH3
Summary
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in spleen (RPKM 3.1), lymph node (RPKM 2.8) and 25 other tissues See more
Orthologs mouse all
Preferred Names
8-oxo-dGDP phosphatase NUDT18
Names
2-hydroxy-dADP phosphatase
7,8-dihydro-8-oxoguanine phosphatase
mutT homolog 3
mutT human homolog 3
nucleoside diphosphate-linked moiety X motif 18
nudix (nucleoside diphosphate linked moiety X)-type motif 18
nudix motif 18
NP_079091.3

 Structure, history

2012: 

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine
            and deoxyguanosine diphosphates: comparison with MTH1 and MTH2
GeneRIF: MTH3 is specifically active against 8-oxo-dGDP and hardly
            cleaves 8-oxo-dGTP. Other types of oxidized nucleoside
            diphosphates, 2-hydroxy-dADP and 8-hydroxy-dADP, were also
            hydrolyzed by MTH3.
NM_024815.4NP_079091.3  8-oxo-dGDP phosphatase NUDT18
aminoacids 1..323 
44..166 "NUDIX hydrolase_13"
https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=240028
76..98,  Nudix, motif
76..97  Nudix box

ORIGIN      
        1 maseglagal asvlagqgss vhscdsapag eppapvrlrk nvcyvvlavf lseqdevlli
       61 qeakrecrgs wylpagrmep getivealqr evkeeaglhc epetllsvee rgpswvrfvf
      121 larptggilk tskeadaesl qaawyprtsl ptplrahdil hlvelaaqyr qqarhplilp
      181 qelpcdlvcq rlvatftsaq tvwvlvgtvg mphlpvtacg ldpmeqrggm kmavlrllqe
      241 cltlhhlvve ikgllglqhl grdhsdgicl nvlvtvafrs pgiqdeppkv rgenfswwkv
      301 meedlqsqll qrlqgssvvp vnr
//

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