NUDT18 (8p21.3), 8-oxo-dGDP phosphatase, MTH3

https://www.ncbi.nlm.nih.gov/gene/79873

MTH3

Summary

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]

Expression

Ubiquitous expression in spleen (RPKM 3.1), lymph node (RPKM 2.8) and 25 other tissues See more

Orthologs mouse all

Preferred Names

8-oxo-dGDP phosphatase NUDT18

Names

2-hydroxy-dADP phosphatase

7,8-dihydro-8-oxoguanine phosphatase

mutT homolog 3

mutT human homolog 3

nucleoside diphosphate-linked moiety X motif 18

nudix (nucleoside diphosphate linked moiety X)-type motif 18

nudix motif 18

NP_079091.3

• EC 3.6.1.58

 Structure, history

2012: 

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine
            and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

GeneRIF: MTH3 is specifically active against 8-oxo-dGDP and hardly
            cleaves 8-oxo-dGTP. Other types of oxidized nucleoside
            diphosphates, 2-hydroxy-dADP and 8-hydroxy-dADP, were also
            hydrolyzed by MTH3.

NM_024815.4 → NP_079091.3  8-oxo-dGDP phosphatase NUDT18
aminoacids 1..323 
44..166 "NUDIX hydrolase_13"
https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=240028
76..98,  Nudix, motif
76..97  Nudix box

ORIGIN      
        1 maseglagal asvlagqgss vhscdsapag eppapvrlrk nvcyvvlavf lseqdevlli
       61 qeakrecrgs wylpagrmep getivealqr evkeeaglhc epetllsvee rgpswvrfvf
      121 larptggilk tskeadaesl qaawyprtsl ptplrahdil hlvelaaqyr qqarhplilp
      181 qelpcdlvcq rlvatftsaq tvwvlvgtvg mphlpvtacg ldpmeqrggm kmavlrllqe
      241 cltlhhlvve ikgllglqhl grdhsdgicl nvlvtvafrs pgiqdeppkv rgenfswwkv
      301 meedlqsqll qrlqgssvvp vnr
//

Related articles in PubMed

1. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. Takagi Y, et al. J Biol Chem, 2012 Jun 15. PMID 22556419, Free PMC Article
2. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Simonis N, et al. Retrovirology, 2012 Mar 29. PMID 22458338, Free PMC Article
3. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article
4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569

See all (10) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

MTH3 is specifically active against 8-oxo-dGDP and hardly cleaves 8-oxo-dGTP. Other types of oxidized nucleoside diphosphates, 2-hydroxy-dADP and 8-hydroxy-dADP, were also hydrolyzed by MTH3.