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torsdag 29 november 2018

NUDT2 (9p13.3) , APAH1 (diadenosine tetraphosphatase)

https://www.ncbi.nlm.nih.gov/gene/318
APAH1
Summary
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in ovary (RPKM 11.6), prostate (RPKM 10.9) and 25 other tissues See more
Orthologs
Preferred Names
bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Names
Ap4A hydrolase 1
Ap4Aase
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase
diadenosine tetraphosphatase
nucleoside diphosphate-linked moiety X motif 2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
nudix motif 2
NP_001152.1

 Structure, history 

  NP_001152.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] 

1991, Dinucleoside tetraphosphatase from human blood cells. Purification
            and characterization as a high specific activity enzyme recognized
            by an anti-rat tetraphosphatase antibody
Conserved Domains (1) summary
cd03428
Location:2140
Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

Related articles in PubMed

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