NUTD11 (Xp11.22), DIPP3b, DIPP3beta, APS1, ASP1

https://www.ncbi.nlm.nih.gov/gene/55190

Also known as

APS1; ASP1; DIPP3b; DIPP3beta; hDIPP3beta

Summary

NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]

Expression

Biased expression in testis (RPKM 29.1), brain (RPKM 16.8) and 4 other tissues See more

Orthologs mouse all

 

Preferred Names

diphosphoinositol polyphosphate phosphohydrolase 3-beta

Names

DIPP-3-beta

DIPP3-beta

diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta

diadenosine hexaphosphate hydrolase (AMP-forming)

diphosphoinositol polyphosphate phosphohydrolase 3, beta

hAps1

nucleoside diphosphate-linked moiety X motif 11

nudix (nucleoside diphosphate linked moiety X)-type motif 11

nudix motif 11

NP_060629.2

• EC 3.6.1.52

• EC 3.6.1.60

 Structure, history

https://www.ncbi.nlm.nih.gov/protein/NP_060629.2

Related articles in PubMed

1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. Hidaka K, et al. J Biol Chem, 2002 Sep 6. PMID 12105228
2. Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. Grisanzio C, et al. Proc Natl Acad Sci U S A, 2012 Jul 10. PMID 22730461, Free PMC Article
3. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. Leslie NR, et al. BMC Biochem, 2002 Jul 16. PMID 12121577, Free PMC Article
4. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Gudmundsson J, et al. Nat Genet, 2008 Mar. PMID 18264098, Free PMC Article
5. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. Fisher DI, et al. J Biol Chem, 2002 Dec 6. PMID 12370170

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. NUDT11, HNF1B, and SLC22A3 genes have roles in prostate cancer pathogenesis
2. Observational study of gene-disease association. (HuGE Navigator)
3. The NUDT11 gene, located on chromosome X, is preferentially expressed in the testis
4. Cloning and characterisation of NUDT11 as a diadenosine polyphosphate-metabolising Nudix hydrolase.

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