NUTD10 (Xp11.22) , DIPP3a, DIPP3-alpha, APS

https://www.ncbi.nlm.nih.gov/gene/170685

lso known as

APS2; DIPP3a; DIPP3-alpha

Summary

This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]

Expression

Biased expression in testis (RPKM 20.6), brain (RPKM 8.6) and 6 other tissues See more

Orthologs all

 

Preferred Names

diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Names

diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha

diadenosine hexaphosphate hydrolase (AMP-forming)

nucleoside diphosphate-linked moiety X motif 10

nudix (nucleoside diphosphate linked moiety X)-type motif 10

nudix motif 10

NP_001291892.1

• EC 3.6.1.52

• EC 3.6.1.60

Structure, history 

ORIGIN      
        1 mkckpnqtrt ydpegfkkra aclcfrsere devllvsssr ypdrwivpgg gmepeeepgg
       61 aavrevyeea gvkgklgrll gvfeqnqdpk hrtyvyvltv telledweds vsigrkrewf
      121 kvedaikvlq chkpvhaeyl eklklggspt ngnsmapssp dsdp
//

Related articles in PubMed

1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. Hidaka K, et al. J Biol Chem, 2002 Sep 6. PMID 12105228
2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. Leslie NR, et al. BMC Biochem, 2002 Jul 16. PMID 12121577, Free PMC Article
3. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Gudmundsson J, et al. Nat Genet, 2008 Mar. PMID 18264098, Free PMC Article
4. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. Fisher DI, et al. J Biol Chem, 2002 Dec 6. PMID 12370170
5. Multiple newly identified loci associated with prostate cancer susceptibility. Eeles RA, et al. Nat Genet, 2008 Mar. PMID 18264097

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

1. Observational study of gene-disease association. (HuGE Navigator)
2. Meta-analysis of gene-disease association. (HuGE Navigator)
3. The NUDT10 gene, located on chromosome X, is preferentially expressed in the testis
4. Cloning and characterisation of NUDT10 as a diadenosine polyphosphate-metabolising Nudix hydrolase.

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