NUTD14 (14q32.33), UGPP, UGPPase, UDPG-pyrophosphatase , UDP-sugar diphosphatase

https://www.ncbi.nlm.nih.gov/gene/256281

Also known as

UGPP; UGPPase

Summary

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Expression

Ubiquitous expression in fat (RPKM 8.0), kidney (RPKM 7.1) and 25 other tissues See more

Preferred Names

uridine diphosphate glucose pyrophosphatase

Names

UDP-sugar diphosphatase

UDPG pyrophosphatase

nudix (nucleoside diphosphate linked moiety X)-type motif 14

NP_001305309.1

• EC 3.6.1.45

 Structure, History, isoform 2

 https://www.ncbi.nlm.nih.gov/protein/NP_001305309.1

Conserved Domains (1) summary

cl00447
Location:39 → 145

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

Related articles in PubMed

1. Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose. Yagi T, et al. Biochem J, 2003 Mar 1. PMID 12429023, Free PMC Article
2. Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication. Wang G, et al. Mol Med Rep, 2016 Mar. PMID 26781650
3. Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. Yuryev A, et al. Genomics, 2003 Feb. PMID 12620389
4. The DNA sequence and analysis of human chromosome 14. Heilig R, et al. Nature, 2003 Feb 6. PMID 12508121
5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article

See all (11) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

the interaction between the RL13 protein and NUDT14 protein may be involved in human cytomegalovirus DNA replication.