NUDT4 (12q44) , DIPP2, Difosfoinositoii-polyfosfaatti-phosphatase 2

https://www.ncbi.nlm.nih.gov/gene/11163

Also known as

DIPP2; NUDT4B; DIPP-2B; HDCMB47P; DIPP2beta; DIPP2alpha

Summary

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]

Expression

Ubiquitous expression in ovary (RPKM 30.0), kidney (RPKM 25.7) and 25 other tissues See more

Orthologs  mouse all

Preferred Names

diphosphoinositol polyphosphate phosphohydrolase 2

Names

DIPP-2

Diphosphoinositol polyphosphate phosphohydrolase NUDT4B

Nucleoside diphosphate-linked moiety X motif 4B

Nudix hydrolase 4B

Nudix motif 4B

diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2

diphosphoinositol polyphosphate phosphohydrolase type 2

nudix (nucleoside diphosphate linked moiety X)-type motif 4

NP_001287951.1

• EC 3.6.1.52

 Structure, History  

NP_061967.3  diphosphoinositol polyphosphate phosphohydrolase 2 isoform alpha

 2000:

Discovery of molecular and catalytic diversity among human
            diphosphoinositol-polyphosphate phosphohydrolases. An expanding
            Nudt family

Related articles in PubMed

1. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family. Caffrey JJ, et al. J Biol Chem, 2000 Apr 28. PMID 10777568
2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. Leslie NR, et al. BMC Biochem, 2002 Jul 16. PMID 12121577, Free PMC Article
3. Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. Caffrey JJ, et al. Gene, 2001 May 16. PMID 11376937
4. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. Fisher DI, et al. J Biol Chem, 2002 Dec 6. PMID 12370170
5. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. Seki N, et al. DNA Res, 1997 Oct 31. PMID 9455484

See all (13) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

This paper demonstrates that KIAA0487 (AB007956) is the 3'-UTR for human diphosphoinositol polyphosphate phosphohydrolase type II