NUDT6 (4q28.1) FGF-AS, FGF2 antisense gene , GFG1

https://www.ncbi.nlm.nih.gov/gene/11162

Also known as

GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS

Summary

This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Expression

Ubiquitous expression in fat (RPKM 12.5), kidney (RPKM 8.8) and 23 other tissues See more

Orthologs  mouse all

Preferred Names

nucleoside diphosphate-linked moiety X motif 6

Names

antisense basic fibroblast growth factor

nudix (nucleoside diphosphate linked moiety X)-type motif 6

 

Related articles in PubMed

1. Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis. Pezzatini S, et al. Bone, 2007 Oct. PMID 17681892
2. Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma. Zhang SC, et al. J Mol Med (Berl), 2007 Nov. PMID 17569023
3. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Asa SL, et al. Mol Endocrinol, 2001 Apr. PMID 11266510
4. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. Gagnon ML, et al. J Cell Biochem, 1999 Mar 15. PMID 10022609
5. FGF-2 antisense RNA encodes a nuclear protein with MutT-like antimutator activity. Li AW, et al. Mol Cell Endocrinol, 1997 Oct 20. PMID 9406864

See all (26) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsF?

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
3. Observational study of gene-disease association. (HuGE Navigator)
4. Thus, survivin, Smac, and PKC alpha might play important roles in the inhibition of apoptosis by FGF-2 in human small cell lung cancer cells.
5. The aim of this study was to characterize the expression of alternatively spliced FGF-AS transcripts and encoded nudix-motif proteins in normal human tissues and in esophageal adenocarcinoma.
6. hydroxyapatite nanocrystals exposure up-regulated FGF-2 mRNA by 6 fold and increased 18 kDa protein isoform by 40%
7. 18-kDa FGF-2 harbors a C-terminal nonclassical bipartite nuclear localization signal, a portion of which also regulates its nucleolar localization.
8. FGF-2 exhibits antitumor activity in vitro and correlates with expression of FGF receptors expression in medulloblastoma cells

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