NUDT3 (6p21.31), DIPP1, difosfoinositolipolyfosfaattihydrolaasi 1

https://www.ncbi.nlm.nih.gov/gene/11165

Also known as

DIPP; DIPP1; DIPP-1

Summary

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

Expression

Ubiquitous expression in brain (RPKM 33.6), thyroid (RPKM 19.6) and 25 other tissues See more

Orthologs mouse all

 

 Structure, history

NP_006694.1  diphosphoinositol polyphosphate phosphohydrolase 1

 

 2002:

 Nudix hydrolases that degrade dinucleoside and diphosphoinositol
            polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP)
            pyrophosphatase activity that generates the glycolytic activator
            ribose 1,5-bisphosphate

 1999:

  Site-directed mutagenesis of diphosphoinositol polyphosphate
            phosphohydrolase, a dual specificity NUDT enzyme that attacks
            diadenosine polyphosphates and diphosphoinositol polyphosphates

1998: 

A novel context for the 'MutT' module, a guardian of cell
            integrity, in a DIPP, diphosphoinositol polyphosphate phosphohydrolase

 NUDIX BOX 51-72  ggmepeeeps vaavrevcee ag

ORIGIN      
        1 mmklksnqtr tydgdgykkr aaclcfrses eeevllvsss rhpdrwivpg ggmepeeeps
       61 vaavrevcee agvkgtlgrl vgifenqerk hrtyvyvliv tevledweds vnigrkrewf
      121 kiedaikvlq yhkpvqasyf etlrqgysan ngtpvvatty svsaqssmsg ir
//

Preferred Names

diphosphoinositol polyphosphate phosphohydrolase 1

Names

diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1

nucleoside diphosphate-linked moiety X motif 3

nudix (nucleoside diphosphate linked moiety X)-type motif 3

nudix motif 3

NP_006694.1

• EC 3.6.1.52

Related articles in PubMed

1. Nudt3 is an mRNA decapping enzyme that modulates cell migration. Grudzien-Nogalska E, et al. RNA, 2016 May. PMID 26932476, Free PMC Article
2. NUDT3 rs206936 is associated with body mass index in obese Japanese women. Kitamoto A, et al. Endocr J, 2013. PMID 23708086
3. Crystal structure of human diphosphoinositol phosphatase 1. Thorsell AG, et al. Proteins, 2009 Oct. PMID 19585659
4. Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates. Yang X, et al. J Biol Chem, 1999 Dec 10. PMID 10585413
5. The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. Safrany ST, et al. J Biol Chem, 1999 Jul 30. PMID 10419486

See all (24) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. Nudt3 is an mRNA decapping enzyme that orchestrates expression of a subset of mRNAs to modulate cell migration and further substantiates the existence of multiple decapping enzymes functioning in distinct cellular pathways in mammals
2. results suggest that NUDT3 rs206936 is associated with body mass index in Japanese women

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